Can CBD be used to treat Angelman syndrome?

In a recent study, researchers at the University of North Carolina wondered if CBD might help treat individuals with a condition involving severe seizures, Angelman syndrome.

What did this study find about CBD and Angelman syndrome?

Angelman syndrome is a neurodevelopmental disorder, in part involving powerful epileptic seizures this study describes as “common” and not responsive to current medications. This study found that in mice, CBD considerably reduced the intensity of seizures brought on by certain stimuli. Research You Can Use has previously looked at peer-reviewed research evidence on using CBD to help manage cravings from opioid use disorder (OUD). As a refresher, pure CBD is a nonintoxicating compound that does not produce a high for individuals using it, or lead to dependence.

THC, by contrast, is a psychoactive compound linked to vaping-related lung disease, produces a high, can produce dependence, and is linked to the negative consequences of marijuana use. CBD and THC are not approved or recommended for use by nursing, pregnant or soon-to-be pregnant women. In this study, researchers tested the effects of CBD on mice with some genetic similarities to humans with Angelman syndrome. They found that acute CBD doses—or 100 mg—reduced seizures in the mice brought on by loud noises and fluctuating body temperature. The study also found that this acute, anticonvulsant CBD caused a “mild sedation” effect in the mice, but did not significantly alter balance or motor function. CBD did not, however, stop the epilepsy-producing “plasticity” in the tested mice. (Continue Reading)

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